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Image Search Results
Journal: Frontiers in Cell and Developmental Biology
Article Title: S100 Calcium Binding Protein Family Members Associate With Poor Patient Outcome and Response to Proteasome Inhibition in Multiple Myeloma
doi: 10.3389/fcell.2021.723016
Figure Lengend Snippet: Prevalence and prognostic significance of S100 copy number change. (A) Location of the 17 S100 genes on chromosome 1q21.3. (B) Hierarchical clustering of S100 genes in CD138+ plasma cells from 168 MM patient samples, using Euclidean distance matrix and complete clustering method, based on CNV score. (C) The increased copy number of S100 genes correlated with poor overall survival. (D) Kaplan-Meier curves for MM patients with or without S100 gain. Because patients with S100 gain were also more likely to have 1q21 gain, four groups were used for OS analysis and included: neither 1q21 gain nor S100 gain (Neither), 1q21 gain present but no S100 gain (only 1q21 gain), S100 gain present but no 1q21 gain (only S100 gain), and 1q21 gain and S100 gain present (Both). CNV score > 0.5 indicated a gain event, while <–0.6 is a deletion event. CNV, copy number variation; FIMM, Institute for Molecular Medicine Finland; OS, overall survival; HR, hazard ratio; CI, confidence interval.
Article Snippet: Mononuclear cells were isolated by Ficoll-Paque gradient centrifugation (GE Healthcare, Little Chalfont, Buckinghamshire, United Kingdom), followed by enrichment of CD138+ plasma cells using the
Techniques: